28 Février – CONFERENCE: Dr. Bertrand PAIN. Mercredi 28 Février 2018, Plateforme de Génomique Fonctionnelle, at 11h
11 h
Stem Cell and Brain Research Institute,
Univ Lyon, Université Lyon 1, U1208, INSERM, USC1361, INRA,
Title: Somatic reprogramming as a tool to get new stem cell types
Pluripotency defines the ability of a cell to self-renew and to differentiate into all of embryonic lineages both in vitro and in vivo. Pluripotent embryonic stem cells (ESCs) were derived from the in vitro culture of pregastrulating embryos. Those cells exhibit unique properties at the molecular, epigenetic and developmental levels, but their derivation was restricted to very few species. Obtaining induced pluripotent stem (iPS) cells with similar properties to those of ESCs remains a challenge and attempts can be launched to derive and establish iPS and iPS-like cells in a large range of species, including avian and mammalian ones. In avian species, we recently showed that the NANOG gene was essential for the long-term establishment of stable clones of reprogrammed cells. In mammals, we derived iPS-like cells from bovine, porcine and equine somatic cells as well as from bat, as a unique model for studying the role of this species as a reservoir for deadly emerging viruses. Interestingly, those different reprogrammed stem cells exhibit unique and specific properties of viral replication of emerging viruses.
