Stem Cells and Cellular Therapies
Stem cell research is a promising field with an alluring potential for therapeutic intervention. Stem cells have unrestricted potential to divide and this strength is used for the regeneration and repair of cells within the body during tissue damage.
Research on stem cells is advancing knowledge about how an organism develops from a single cell and how healthy cells replace damaged cells in adult organisms. This promising area of science is also leading scientists to investigate the possibility of cell-based therapies to treat disease.
In this task, based on our expertise in stem cells and cellular therapies, we provide here:
- Basic research projects on the fundamental aspects on stem cells, the different sources, their potency, and their significant role in regenerative medicine for treatment of various diseases [Human induced pluripotent stem (hiPSCs) disease modelling for studying neurodegenerative disorders like Parkinson’s disease, and inherited liver diseases]
- Cellular and gene biotherapies by using mesenchymal stem cells (MSCs) or hiPSCs for treating neurodegenerative, hepatic and hematopoietic disorders, for building tissue-engineered constructs using stem cells and biomaterials, mainly in the field of bone, vascular, and skin regeneration
- Preclinical and clinical translation
- Societal and ethical issues of their use
Representative publications
- A.H.V. Schapira, C.W. Olanow, J.T. Greenamyre, E. Bezard. Slowing neurodegeneration in Parkinson disease and Huntington disease: Future therapeutic perspectives. Lancet 2014, 384 (9942):545-555.
- Rouault-Pierre K, Lopez-Onieva L, Foster K, Anjos-Afonso F, Lamrissi-Garcia I, Serrano-Sanchez M, Mitter R, Ivanovic Z, de Verneuil H, Gribben J, Taussig D, Rezvani HR, Mazurier F, Bonnet D. HIF-2α protects human hematopoietic stem/progenitors and acute myeloid leukemic cells from apoptosis induced by endoplasmic reticulum stress. Cell Stem Cell. 2013 Nov 7;13(5):549-63. doi: 10.1016/j.stem.2013.08.011.
- Mathieu ME, Faucheux C, Saucourt C, Soulet F, Gauthereau X, Fédou S, Trouillas M, Thézé N, Thiébaud P, Boeuf H. MRAS GTPase is a novel stemness marker that impacts mouse embryonic stem cell plasticity and Xenopus embryonic cell fate.Development. 2013 Aug;140(16):3311-22
- Bedel A, Taillepierre M, Guyonnet-Duperat V, Lippert E, Dubus P, Dabernat S, Mautuit T, Cardinaud B, Pain C, Rousseau B, Lalanne M, Ged C, Duchartre Y, Richard E, de Verneuil H, Moreau-Gaudry F. Metabolic Correction of Congenital Erythropoietic Porphyria using iPSCs free of Reprogramming Factors. Am J of Human Genetics 2012; 91(1):109-21.
- Li H, Daculsi R, Grellier M, Bareille R, Bourget C, Amedee J. Role of neural-cadherin in early osteoblastic differentiation of human bone marrow stromal cells cocultured with human umbilical vein endothelial cells. Am J Physiol Cell Physiol. (2010) Aug;299(2):C422-30.
Coordinators
H. Boeuf (CNRS UMR 5134) and F. Moreau-Gaudry (Inserm U 1035)
