Tissue Engineering and Biofabrication
With aging population, there has been an ever-increasing demand for organ transplants. A potential solution to this problem is to grow or fabricate organs and tissues using biomaterial scaffolds and a person’s own cells in a specific 3-dimensional and mechanical environment. Although the realization of these tissue engineering strategies has proved their potential in experimental studies, only few clinical assays have been developed, The development of new biofabrication approaches open new trategies for personalized regenerative medicine.
In this task, based on our expertise on tissue engineering strategies, we provide here:
- Multifunctionalized and microstructured materials able to accommodate cells with respect to their phenotypes, to allow cell division and function to the expected tissue, to maintain the integrity of the surrounding tissue, and use their signaling machinery to serve the development of the appropriate neo-tissue.
- Innovative scaffolds as delivery systems for growth factors or molecules (anti-inflammatory..) for the regulation of tissue development
- Innovative strategies of tissue biofabrication (3D bioprinting, Laser assisted Bioprinting, Ink Printer, Extrusion systems) for personalized medicine.
The main applications concern orthopaedic, oral surgery, vascular substitution, kidney tissue engineering and skin reconstruction.
Representative publications
- Thébaud NB, Aussel A, Siadous R, Toutain J, Bareille R, Montembault A, David L, Bordenave L. Labeling and qualification of endothelial progenitor cells for tracking in tissue engineering: An in vitro study. Int J Artif Organs. 2015 Apr;38(4):224-32.
- H.R Rezvani, N. Ali, M. Serrano-Sanchez, P. Dubus, C. Varon, C. Ged, C. Pain, M Cario-André, J. Seneschal, A. Taieb, H. de Verneuil, F. Mazurier. Loss of epidermal hypoxia-inducible factor-1α accelerates epidermal aging and affects re-epithelialization in human and mouse. J Cell Sci. 2011; 124: 4172-83
- Chollet C, Bareille R, Rémy M, Guignandon A, Bordenave L, Laroche G, Durrieu MC. Impact of peptide micropatterning on endothelial cell actin remodeling for cell alignment under shear stress. Macromol Biosci. 2012 Dec;12(12):1648-59. doi: 10.1002
- Fricain JC, Schlaubitz S, Le Visage C, Arnault I, Derkaoui SM, Siadous R, Catros S, Lalande C, Bareille R, Renard M, Fabre T, Cornet S, Durand M, Léonard A, Sahraoui N, Letourneur D, Amédée J.A nano-hydroxyapatite--pullulan/dextran polysaccharide composite macroporous material for bone tissue engineering. Biomaterials. (2013) Apr;34(12):2947-59.
- Guillotin B, Souquet A, Catros S, Duocastella M, Pippenger B, Bellance S, Bareille R, Rémy M, Bordenave L, Amédée J, Guillemot F. Laser assisted bioprinting of engineered tissue with high cell density and microscale organization. Biomaterials. (2010) Oct;31(28):7250-6
Coordinators
N. L'Heureux (Inserm U 1026) and A. Taieb (Inserm U 1035)
